Viene riscontrato in casi di alopecia areata basso livello di folato in RBC, in correlazione inversa a gravità e l’estensione della alopecia.
Indian J Dermatol. 2014 Nov;59(6):630. – Evaluation of Serum Homocysteine, High-Sensitivity CRP, and RBC Folate in Patients with Alopecia Areata. Yousefi M1, Namazi MR2, Rahimi H1, Younespour S1, Ehsani AH3, Shakoei S1.
Alopecia areata (AA) is a common type of hair loss with an autoimmune basis. As the role of homocysteine (Hcys), folate, and CRP has been considered in some autoimmune diseases.
OBJECTIVES: To evaluate homocysteine, folate and CRP level in alopecia areata.
METHODS: This study was performed on 29 patients who had AA for at least 6 months affecting more than 20% of scalp, and 32 healthy controls. Levels of serum Hcys, blood high-sensitivity CRP, and RBC folate were measured in all subjects.
RESULTS: The mean level of RBC folate was significantly lower in the patient group than that in controls (P < 0.001).
Also, the level of RBC folate was significantly lower in patients with extensive forms of disease (alopecia totalis/alopecia universalis) in comparison with more localized form (patchy hair loss) (P < 0.05).
Patients with higher “Severity of Alopecia Total” (SALT) score had lower RBC folate, as well.
Serum Hcys and blood high-sensitivity CRP levels did not show a significant difference in two groups.
CONCLUSION: Patients with alopecia areata have lower level of RBC folate which is in negative correlation with both severity and extension of Alopecia Areata.